Pharming

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jack.
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Re: Pharming

Berichtdoor jack. » 09 Aug 2018 08:28

https://angioedemanews.com/2018/07/19/s ... ross-body/



Specific Inhibitors Efficiently Treat Acute HAE Attacks in Various Body Locations, Study Reports


July 19, 2018
Jose Marques Lopes, PhDby Jose Marques Lopes, PhD

Specific Inhibitors Efficiently Treat Acute HAE Attacks in Various Body Locations, Study Reports





Treatment of hereditary angioedema (HAE) with C1-esterase inhibitors (C1-INH) provides efficient relief of acute attacks across different locations of the body, according to a new study.

The research was presented at the 2018 American Academy of Allergy Asthma & Immunology (AAAAI)/World Allergy Organization (WAO) Joint Congress, which took place in Orlando, Florida.

The poster was titled “Efficacy of Recombinant Human C1 Esterase Inhibitor (rhC1INH) Across Anatomical Locations in Acute Hereditary Angioedema (HAE) Attacks.”

Patients with HAE have reduced levels or a dysfunction of either C1-INH protein, or coagulation factor XII. While factor XII is involved in blood clotting, C1-INH controls inflammation.

If lacking (in HAE type 1) or functioning abnormally (type 2), patients experience episodes of swelling due to the excessive production of a pro-inflammatory protein fragment called bradykinin.

The use of engineered, or recombinant, human forms of C1-INH (rhC1-INH) is a common approach in the treatment of acute hereditary angioedema attacks, which aims to increase the amount of C1-INH in the blood. Ruconest, marketed by Pharming Group, is an approved medication using this strategy.

Despite a known effectiveness, information on whether the time to ease HAE symptoms varies across different body locations was lacking.

Aiming to address this gap, the researchers used data from two double-blind trials with open-label extensions, which refers to study periods with no use of placebo. Patients ages 12 and older with acute hereditary angioedema attacks were randomly assigned to either rhC1-INH 50 U/kg or a placebo.

The start of symptom relief at an attack location was assessed with the visual analog scale (VAS), which has been used to evaluate severity of acute attacks in hereditary angioedema.

The results showed that treatment with rhC1-INH shortened the mean time to symptom relief in all HAE attack locations compared to placebo, including abdominal (60 vs. 240 minutes), peripheral — which may affect the hands, arms, legs, feet, or genitals (105 vs. 303 minutes) — oro-facial-pharyngeal-laryngeal, which spans the mouth, face, jaw, pharynx, and larynx (64.5 vs. 306 minutes), and urogenital attacks (119 vs. 320 minutes).

Time to start relief of facial attacks was 158 minutes with rhC1-INH. The researchers were unable to determine the corresponding result in the group receiving placebo.

“Treatment with rhC1INH 50 U/kg was efficacious in shortening time to symptom relief of acute HAE attacks, regardless of attack location,” the scientists wrote.
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jack.
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Re: Pharming

Berichtdoor jack. » 09 Aug 2018 08:33

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Sictic
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Re: Pharming

Berichtdoor Sictic » 09 Aug 2018 09:16

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Re: Pharming

Berichtdoor micado » 09 Aug 2018 10:48

Sictic schreef:https://clinicaltrials.gov/ct2/show/NCT02869347


"Iodinated contrast media have been causally linked to acute kidney injury known as contrast-induced nephropathy (CIN), which is the consequence of CM-induced local renal ischemia and direct toxic effects. Conestat alfa (recombinant human C1 esterase inhibitor) has been shown to decrease renal ischemic damage in experimental models of renal ischemia."

https://clinicaltrials.gov/ct2/show/NCT02869347

Nu nog wachten op de resultaten. ;-) Gewoon blijven zitten en een paar dagen geduld :D
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micado
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Re: Pharming

Berichtdoor micado » 09 Aug 2018 12:40

We zitten op de goede weg - tweed Nico Bakker

"PHARMING mag een augustus rally naar 1,40 laten zien, opleving in de downtrend. Ik bespreek de chart in het Lunch Webinar."

https://twitter.com/TheDailyTurbo/statu ... 9726006272
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Re: Pharming

Berichtdoor Soppi » 09 Aug 2018 16:17

I like it!!
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Re: Pharming

Berichtdoor lode78 » 09 Aug 2018 16:26

met al dat geshort staat pharming sowieso veel te laag genoteerd...blij voor de shorters dat ze af en toe paar 100 euro verdienen

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Re: Pharming

Berichtdoor sepan » 09 Aug 2018 16:34

Soppi schreef:I like it!!


It's cover time :lol:
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Re: Pharming

Berichtdoor sepan » 10 Aug 2018 09:04

Vandaag terug boven de 1.35 € ??

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Re: Pharming

Berichtdoor Msb12i » 10 Aug 2018 09:17

sepan schreef:Vandaag terug boven de 1.35 € ??



Er zal vandaag niet veel positief eindigen vrees ik...
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